Category Archives: Pathology

Pathology: ischemic hepatopathy

You’re thinking to yourself, hmm, why is this slide titled ischemic hepatopathy?  You don’t see any hepatocyte necrosis.  No macrophage activity.  No inflammation.  This post is a sham!  Just a minute… The purpose of using this histologic specimen is for … Continue reading

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Pathology: prurigo nodularis

Prurigo nodularis can be seen in liver disease.  Pruritus develops after the deposition of bile acids in the skin.  Repetitive scratching can, in some patients, lead to the development of hyperpigmented nodules.  This finding does not require skin biopsy.  The … Continue reading

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Pathology: ocular herpes

   A middle aged female 3 years post liver transplant presented to the hospital with a similar ocular finding to the one in the image above.  She was leukopenic.  Ocular herpes was diagnosed. There was involvement of the central nervous system as … Continue reading

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Pathology: stellate cell

The hepatic stellate cell is a connective tissue cell that, in its quiescent state, helps to regulate vitamin A metabolism (storage, release, etc.).  However, it is constantly surveying its environment and, during liver injury, transforms into a myofibroblast phenotype, and participates in the homeostasis … Continue reading

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Pathology: hepatic sinusoid

The sinusoid is the smallest caliber blood vessel in the liver.  Functionally, it connects the portal veinules (inflow) to the hepatic vein (outflow).  Kupffer cells, the resident macrophages of the liver, dwell within the sinusoid and send signals to nearby … Continue reading

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Pathology: alopecia

Alopecia is sometimes seen in cirrhotic patients, though the exact mechanism is not well understood.  It is likely related to a deficiency of vitamins, minerals and proteins, some of which the liver is responsible for producing.  While there are no … Continue reading

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Pathology: cellulitis

What happens when the cirrhotic patient has evidence of lower extremity cellulitis, as in the image above?  Do you prescribe antibiotics (5-10 days) and send the patient home?  Here are some additional considerations… The immunocompromised patient is at risk for … Continue reading

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