Category Archives: Journal Club

Journal Club: statins prevent hepatocellular carcinoma

Today’s journal club focused on whether statins prevent hepatocellular carcinoma (HCC).  It was a meta-analysis from a recent Gastroenterology publication (see link below).  Statins (HMG-CoA reductase inhibitors) influence a long cascade of reactions that may affect neoangiogenesis (ie. Ras pathway), and are … Continue reading

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Journal Club: enoxaparin use in cirrhosis

This journal club dealt with enoxaparin for cirrhotic patients.  Anticoagulation for cirrhotic patients? Yes. The concept behind this trial was that there are microthromboses at the level of bowel wall perfusion that lead to subtle ischemic damage and subsequent increased permeability.  … Continue reading

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Journal Club: azathioprine metabolites predict remission in autoimmune hepatitis

Today’s journal club centered on the metabolites of azathioprine (aza) and how they affect the clinical course of autoimmune hepatitis.  Recall that aza is a prodrug, which is cleaved to 6-MP.  This is then metabolized by TPMP and XO to inactive … Continue reading

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Journal Club: vitamin D for HCV

Vitamin D deficiency has been shown to alter susceptibility to viral infections like influenza, respiratory tract infections and HIV.  It also may play a role in chronic liver disease!  Studies show that vitamin D deficiency at the outset of HCV treatment … Continue reading

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Journal club: vascular complications of orthotopic liver transplantation

This recent article, published in the J Amer Coll Surg (see link below) analyzed the experience of over 4,000 liver transplants, and specifically at the outcomes of portal vein thrombosis (PVT) and hepatic artery thrombosis (HAT).  Rates of graft loss … Continue reading

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Journal club: Transplantation for severe alcoholic hepatitis

Today’s journal club focused on an article from November, 2011, published in the New England Journal of Medicine.  It dealt with survival outcomes for patients transplanted with severe alcoholic hepatitis.  Although 7 European centers were listed as participatory, only 3 … Continue reading

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Journal club: primary prophylaxis for SBP

This journal club evaluated the merits of primary antibacterial prophylaxis for SBP.  Two articles were reviewed.  The first was a 2007 Gastroenterology paper from Fernandez et al.  They randomized 68 patients to norfloxacin or placebo.  The key point here is: … Continue reading

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