Definition: mixed cryoglobulinemia

Mixed cryoglobulinemia is a Type II/III vasculitic disorder seen in hepatitis C and hepatitis B infections (as opposed to Type I cryoglobulinemia that occurs as a monoclonal blood dyscrasia, ie. multiple myeloma).  Although purpura, glomerulonephritis and arthralgia are hallmarks of the disease, symptoms like fatigue, weakness, Raynaud’s phenomenon and peripheral neuropathy are also described.

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