Definition: NS3, NS4a, NS5a, NS5b

NS3, NS4a, NS5a and NS5b are all “non-structural” loci on the HCV replicon that are targets for the newest therapies, termed nucleoside/tide and non-nucleoside/tide inhibitors.  By combining oral drugs of these various mechanistic categories for the eradication of hepatitis C virus, SVR rates are likely going to exceed 90%.

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