Monthly Archives: November 2012

Pathology: alopecia

Alopecia is sometimes seen in cirrhotic patients, though the exact mechanism is not well understood.  It is likely related to a deficiency of vitamins, minerals and proteins, some of which the liver is responsible for producing.  While there are no … Continue reading

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Lecture: cholangiocarcinoma

Today’s lecture focused on the topic of cholangiocarcinoma (CCA).  It is a rare tumor, and nearly 70% of them occur sporadically. However, there are several known risk factors, with the most common one being primary sclerosing cholangitis (PSC).  Many cases … Continue reading

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Exception

MELD exception points for hepatocellular carcinoma began at 29 and have been reduced on two occasions since.  Experts in the field still believe 22 points is excessive, and HCC patients are given an unfair advantage over ESLD patients.

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Journal Club: azathioprine metabolites predict remission in autoimmune hepatitis

Today’s journal club centered on the metabolites of azathioprine (aza) and how they affect the clinical course of autoimmune hepatitis.  Recall that aza is a prodrug, which is cleaved to 6-MP.  This is then metabolized by TPMP and XO to inactive … Continue reading

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The Sunday Chronicles

Week #30 snapshot, and another uncomfortable patient phone call.

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Ligation

Although variceal band ligation is considered to be equivalent to beta blockade for the primary prophylaxis of bleeding, in meta-analyses, it is a few percentage points superior to beta blockade.

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Terrorism, liver; C. burnetii

Coxiella burnetii is a gram negative bacteria that causes Q fever. It can cause hepatomegaly as well as hepatitis.

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