Definition: ischemia/reperfusion injury

Ischemia/reperfusion injury occurs after temporary deprivation of blood flow to oxygen-dependent hepatocytes followed by reperfusion, as in the cases of liver transplantation, partial hepatectomy and various forms of circulatory shock.  When this phenomenon happens, a complex series of detrimental events happens, including release of reactive oxygen species, production of inflammatory cytokines, and hepatocyte death via apoptosis and necrosis.

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