Monthly Archives: July 2012

Terrorism, liver; ricin

Ricin, from the castor oil plant (photo below), is highly toxic when swallowed, injected or inhaled.  It can cause an elevation in transaminases. Toxico-terrorism. McGraw-Hill, 2007; pp 89-100 Advertisements

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Hepatocellular carcinoma

Question: Which of the following risk factors is not associated with the development of hepatocellular carcinoma? A. hepatitis B viral genotype B. male gender C. HVPG D. portal vein thrombosis   Answer: Hepatocellular carcinoma (HCC) arises in a cirrhotic liver in … Continue reading

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The Sunday Chronicles

News Headline: Hepatitis C fears spread across the country.  Editorial: Don’t rush to see your local hepatologist.  Don’t share your toothbrush either.

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In the academic setting, an innovative initiative can find success only when the recipient is receptive.  – Anonymous

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Pathology: Kupffer cells

The resident hepatic macrophage, the Kupffer cell, has many important roles in health maintainance and injury.  In the the histologic specimen above, the Kupffer cells are stained dark brown.  They line the hepatic sinusoids. Historically, this macrophage’s role lied in phagocytic clearance of … Continue reading

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Pathology: buffalo hump

The buffalo hump develops in patients who are on long term prednisone therapy.  In hepatology, this is most frequently encountered in patients being treated for autoimmune hepatitis.  Prednisone should be minimized, if not altogether discontinued, within 6-12 months of starting; … Continue reading

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Clinical Pearl

The average time it takes for a hepatitis C patient to progress from one stage of fibrosis to the next is 7 years.  In addition, there are slow fibrosers and rapid fibrosers, and having other conditions like alcohol use, NASH or … Continue reading

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