Pathology: Mallory’s hyaline

When we speak of ‘hyaline’ on a liver biopsy, we are usually referring to Mallory’s haline (the ropy, pink substance you see at 6 o’clock in the cytoplasm of the central hepatocyte).  Mallory’s hyaline is very suggestive of alcohol as the etiology of steatosis, and less frequently described in the setting of NASH.  It may take several months for hyaline to regress after a patient becomes abstinent of alcohol.

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