Pathology: hepatic granuloma

It is not uncommon to see a granuloma on a liver biopsy.  Granulomatous disease carries a broad diferential diagnosis.  You should consider sarcoidosis, primary biliary cirrhosis, drug effect, tuberculosis (if necrotizing), and schistosomiasis.  Furthermore, it could be idiopathic and completely benign; that would be a diagnosis of exclusion. 

Notice in the histologic specimen above the well-circumscribed collection of cellular debris, containing some inflammatory cells (neutrophils are the multi-lobed cells), bile ducts, necrotic tissue and extracellular matrix.

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