Definition: diuretic-resistant ascites

Diuretic-resistant ascites occurs late in the couse of ascites (10-20% of cases) as the proximal convoluted tubule becomes increasingly sodium-avid. The patient will be on a sodium-restricted diet of < 2,000 mg/day, on full-dose diuretics (furosemide 160 mg, spironolactone 400 mg) and unable to diurese effectively (ie. lose weight).

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