Definition: lipopolysaccharide

Lipopolysaccharide (LPS), a component of the cell wall of gram-negative bacteria, is found in increased portal and systemic concentrations in several liver diseases including alcoholic liver disease, hepatopulmonary syndrome and NASH.  New data even suggest its role in the development of obesity and metabolic syndrome, so additional research is needed to elucidate the relationship between gut microbial flora and the inflammatory/fibrogenic mechanisms associated with the gut-liver axis.

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