Clinical Pearl

What does this photo have to do with post-transplant immunosuppression?

The discovery started with the efforts of a Canadian expedition, in the 1960s, to Easter Island (Rapa Nui in the native language) to gather plant and soil samples for subsequent analyses. Importantly, one of these soil samples contained the bacterium Streptomyces hygroscopicus that was found to produce a secondary metabolite, now known as rapamycin, with potent antifungal activity. Not long after it was initially characterized as an antifungal agent, rapamycin was found to possess cytostatic activity not only against lower eukaryotes but also against mammalian cells, particularly immune cells and human tumour cells xenografted into rodents.

To read more about this discovery, click here:

http://www.molbio.unige.ch/files/pmid/21428915.pdf

 

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