Definition: liver X receptor

The liver X receptor is a nuclear receptor (found on hepatocytes, Kupffer cells, endothelial and stellate cells) with several functions, including cholesterol transport, lipogenesis and anti-inflammatory signaling.  Recently, the LXR was shown in animal models to suppress stellate cell activation and fibrogenesis, making it a potential target for antifibrotic therapy (J Hep. 2011;55:1452-54).

This entry was posted in Definition. Bookmark the permalink.

Leave a Reply

Please log in using one of these methods to post your comment: Logo

You are commenting using your account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s