Definition: liver X receptor

The liver X receptor is a nuclear receptor (found on hepatocytes, Kupffer cells, endothelial and stellate cells) with several functions, including cholesterol transport, lipogenesis and anti-inflammatory signaling.  Recently, the LXR was shown in animal models to suppress stellate cell activation and fibrogenesis, making it a potential target for antifibrotic therapy (J Hep. 2011;55:1452-54).

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