Equilibration

The reason we start to diurese ascites with spironolactone and not furosemide is for its site of action, at the (distal) collecting tubule.  If you begin with a loop diuretic instead (like furosemide) and create a sodium gradient more proximally, the sodium-avid kidney will re-equilibrate itself and dilute the urine you tried to create by the time it reaches the collecting tubule.

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