Definition: SHARP trial

The SHARP trial was the first publication to show a survival advantage (albeit only 3-4 months) in a chemotherapy arm for hepatocelluar carcinoma (NEJM, 2008 – see below); the patients all had advanced HCC and were therefore beyond transplantation criteria. The study arm suffered more diarrhea, weight loss, hand-foot skin reaction and hypophosphatemia.

http://www.nejm.org/doi/full/10.1056/NEJMoa0708857

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