Clinical Pearl

Hepascore (liver fibrosis panel) for detection of fibrosis in NASH? This complex model was originally validated for fibrosis scoring in hepatitis C. In NASH, the utility is very limited. In a recent article [Adams et al. Journ Gastro & Hepatol, 2011] Hepascore was evaluated and compared to simple models like APRI (the AST to platelet ratio index). Hepascore was unable to reliably detect significant fibrosis (F2-4), but was able to detect advanced fibrosis (F3-4) and cirrhosis (F4) with reasonable efficacy. Nevertheless, if the risk factors for advanced fibrosis are there (ie. obesity, diabetes, advanced age) and the clinical suspicion is there, do not rely on these non-invasive markers; go for liver biopsy.

Advertisements
This entry was posted in Clinical Pearl. Bookmark the permalink.

Leave a Reply

Please log in using one of these methods to post your comment:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s