Pathology: Mallory-Denk body

The Mallory-Denk body is a pink, “rope-like” inclusion in the cytoplasm of hepatocytes. It represents an aggregation of filaments of the cell’s cytoskeleton. It is synonymous with the term “hyaline” when discussing the histology of alcoholic liver disease.

In the specimen above, notice the Mallory hyaline at 6 o’clock in the center hepatocyte.

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