Clinical Pearl

Some of the prominent histologic features of alcoholic liver disease include: steatosis, Mallory bodies, perivenular fibrosis, ballooning degeneration and a neutrophilic infiltrate (neutrophils are attracted to lipid peroxidative damage). Out of these, the neutrophils should be first to disappear with abstinence; therefore, the persistence of a neutrophilic infiltrate suggests ongoing alcohol abuse.

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