Definition: recombinant factor VIIa

Recombinant factor VIIa, despite its risk for thrombosis, can be used in the cirrhotic patient when bleeding is a result of an inadequate coagulation system (ie. massive hematomas, or post-procedural bleeding: dental extractions, liver biopsy, paracentesis).  Its use is likely to be futile in the settings of intraoperative bleeding, portal hypertensive bleeding, severe acidosis or severe deficiency of procoagulant proteins (factors X, V, II and fibrinogen).

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