Clinical Pearl

The two, new protease inhibitors (PI) telaprevir and boceprevir can be confusing, with respect to duration of use.  As a general rule, use telapravir (as part of triple therapy) from day 1 for a total of 12 weeks, then finish the course with Peg and Riba; use bocepravir after a 4-week lead in phase with Peg & Riba, for the remainder of therapy.

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