Monthly Archives: May 2011

Journal club: Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma

This journal article (J. Hepatol, May 2011)  focused on the histologic microenvironment that surrounds hepatocellular carcinoma.  In particular, we discussed the interaction between IL-17 producing lymphocytes and peritumoral neutrophils.  The Chinese authors of this study (see link below) were able to … Continue reading

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The Sunday Chronicles

“May 21 came and went, and the world is still here.  So no more excuses- get that colonoscopy!“

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Definition: alpha-1 antitrypsin deficiency

Alpha-1 antitrypsin deficiency is an inherited disorder of protein folding that occurs inside hepatocytes, such that the dysfunctional protein accumulates and leads to chronic inflammation and scar.  Since the a-1AT protein is not sufficiently exported to the lung, it cannot protect against … Continue reading

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Cytomegalovirus (CMV)

Question: A 66 year old male liver transplant recipient is seen in clinic one month after transplant. He is troubled by the number of medications he’s on and wants to know whether he can discontinue some of them, in particular, Valcyte.  … Continue reading

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Lecture: HBV drug resistance patterns

This lecture focused on the drug resistance patterns in hepatitis B viral infection.  There are at least five recognized mutation patterns, and it is important to recognize drug resistance when it appears.  Typically, while a patient is on therapy and … Continue reading

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Never make relationship assumptions when greeting your patient and companion, lest the brother turns out to be the wife. – Cohen

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Definition: lipofuscin

Lipofuscin is a granular, brownish “wear and tear” pigment found in the cytoplasm of macrophages and hepatocytes.  It represents the indigestible, lipid-containing residue of degradation, and is suggestive of the “cleaning up” of a recent injury.

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