Definition: cholestasis of sepsis

Cholestasis of sepsis involves a direct hyperbilirubinemia, and occurs most frequently with a bacterial infection in the ICU.  It is thought to be related to dysfunction of the BSEP (bile salt export protein) transporter or MRP2 transporter, and patients with heterozygosity for PFIC/BRIC mutations are thought to be more predisposed to this condition.

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