Definition: diuretic refractory ascites

Diuretic refractory ascites occurs in the advanced stages of portal hypertension, whereby maximal doses of diuretics (furosemide 160 mg daily; spironolactone 400 mg daily) cannot be administered due to a side effect.  The four cardinal side effects include: renal insufficiency, hyponatremia, hepatic encephalopathy, and hyper/hypokalemia.

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